MuscleMeds Hexaghen

HEXAGHEN- The Next Generation of Bodybuilding Freaks Are Coming!




THE SCIENCE BEHIND HEXAGHEN

DESCRIPTION:




HEXAGHEN FastSorb tablets belong to a new class of orally effective IGF-1 (Insulin-Like Growth Factor-1) stimulating compounds. HEXAGHEN utilizes a FastSorb delivery system for rapid absorption and maximum bioavailability.

ACTIVE COMPOUNDS:

HEXAGHEN FastSorb tablets for oral administration contain IGF-1 Optimizing synergistic compounds:
GHRP-2 Hexapeptide Acetate
cis -4, 17(20)-pregnadiene-3,16-dione
trans-4, 17(20)-pregnadiene-3,16-dione

THE SCIENCE OF INSULIN-LIKE GROWTH FACTOR-1 (IGF-1)

IGF-1 produced in the body possess some unique anabolic characteristics and is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and multiplication. Attention was first turned to IGF-1 when scientists researching growth hormone discovered that Growth Hormone (GH) influence on IGF-1 production was the responsible factor for the anabolic effects associated with growth hormone administration and natural elevation in the body. In fact, while GH has direct fat burning effects as it metabolizes stored body fat, its muscle building effects are actually attributed to its effects on increasing IGF-1 levels. Therefore, it is IGF-1 and not GH that directly mediates muscle cell hyperplasia and muscle growth at the cellular level. IGF-1 is thought to be the critical mediator as it stimulates both the differentiation and proliferation of myoblasts (muscle cells), resulting in muscle growth. IGF-1 also enhances muscle growth by increasing amino acid uptake and protein synthesis.

IGF-1 is an important peptide hormone that is involved in regulating growth and development of muscle tissue. Its primary action is mediated by binding to specific IGF-1 receptors present on many cell types in many tissues. The free form IGF-1 fraction is highly bio-active in comparison to the IGF-1 bound to IGF Binding Proteins (IGFBPs). IGF-1 is the principal hormonal mediator of growth in the body. In the cascade of biochemical events leading to a surge in IGF-1 production and levels, HEXAGHEN stimulated growth hormone is metabolized by the liver and potentiates the synthesis and secretion of IGF-1.

Muscle tissue has an abundance of IGF-1 receptors. When serum IGF-1 binds to these receptor sites on muscle tissue, it stimulates the following anabolic actions and growth processes in humans, including increasing the number and size of muscle cells:

•Regulates cell growth and development
•Regulates cellular DNA synthesis
•Mediates muscle cell hyperplasia and muscle fiber development initiation and maturation.
•Stimulates the growth and size of muscle cells
•Stimulates glucose uptake by myoblasts (muscle precursor cells), which fuels their growth and development into muscle fiber cells
•Increases muscle cell uptake of amino acids, uses as building blocks of muscle protein molecules
•Increases nitrogen retention and a greater food conversion efficiency
•Reduces nitrogen excretion
•Improves wound healing
•Stimulates muscle protein synthesis
•Preferentially stimulates the growth of lean tissue
•Stimulates mitogenic (cell replication) activities that lead to an increased number of muscle cells in the body
•Vital for muscle repair and regeneration
•Causes improvements in body composition, demonstrating a decrease in body fat mass and a profound increase in lean body mass
The relationship within the endocrine/IGF-1 axis is a complex system. Scientists have recently identified other factors that play a critical role in effecting IGF-1 levels. Approximately 98% of IGF-1 is bound to one of several insulin-like growth factor binding proteins (IGFBP). IGFBP-3, the most abundant protein, accounts for 80% of all IGF-1 binding. Research has demonstrated that reducing IGF-1 binding proteins and maintaining higher levels of free IGF-1 is correlated to improved anabolic effects and muscle development.

As reported in independent research journals, thyroid function is also associated with enhancing IGF-1 bio-active tissue levels and further increasing the rate of protein synthesis. Therefore, as IGF-1 levels are increased, a series of negative feedback controls involving the thyroid endocrine axis are triggered to keep IGF-1 levels within a narrow physiological range; not too high and not too low. From examining the relationships between GH, IGF-1 production, IGF-1 levels, free IGF-1, IGFBP, and thyroid function, MuscleMeds researchers addressed
this correlation between IGF-1 production and bio-effectiveness related to thyroid stimulation. HEXAGHEN’s synergistic thyroid
involvement is designed to help sustain higher total and free IGF-1 levels for longer periods of time, thereby extending the overall desired
IGF-1 anabolic effects.

Research and Development

The muscle building effects of IGF-1 have been well known and medically documented for years. But, the controlling factors regulating the body’s natural output have challenged researchers. Synthetic IGF-1 has been produced by major biotech pharmaceutical companies on a large scale using recombinant DNA technology. These synthetic forms must be administered via injection dosing. The development of an orally effective IGF-1 enhancing compound has long been a major global objective of biotechnologists.

After years of extensive research and laboratory analysis, MuscleMeds researchers discovered a unique IGF-1 stimulating hexapeptide
(GHRP-2 Hexapeptide Acetate). Due to its long hexapeptide structure, the development of an effective oral dosage form for GHRP-2 Hexapeptide posed some biotechnical challenges. Conventional oral dosing (such as tablets, capsules, liquids and softgels) was ineffective due to the gastrointestinal destruction of the GHRP-2 hexapeptide. As with other peptide substances, GHRP-2 hexapetide is subject to destruction (breakdown) in the gastrointestinal system, which eliminates the effectiveness and ability to reach the hypothalamus-pituitary axis. In order to create a product that is suitable for oral administration of the HEXAGHEN GHRP-2 Hexapeptide acetate, MuscleMeds scientists employed the utilization of their proprietary FastSorb delivery system technology.

INDICATIONS AND USAGE

Hexaghen is intended for use by individuals over the age of 18 to help increase IGF-1 levels, for the promotion and stimulation of lean muscle tissue, when used in conjunction with proper nutrition, strength training, and muscle building programs.

DOSAGE AND ADMINISTRATION

Directions: Hexaghen Fastsorb tablets are designed to be dissolved slowly in the mouth for sub-buccal absorption. Hexaghen should be taken 30 minutes before bedtime. Place two (2) Hexaghen Fastsorb tablets under your tongue and let dissolve completely, then swallow.
Do Not Excede Two (2) Tablets Per Day.

6 Week Cycling Instructions

2 Weeks on (14 days)

1 Week off (7 days)

2 Weeks on (14 days)

1 Week off (7 days)

(Then Repeat Cycle)

WARNINGS:

Not for use by individuals under the age of 18 years. Do not use if pregnant or nursing. Consult a physician or licensed qualified health care professional before using this product. Do not exceed recommended serving. Discontinue use and call a physician or licensed qualified health care professional immediately if you experience any adverse effects. To report any adverse event call 1-800-332-1088.

Interactions with Testosterone: The Increased Anabolic Effects of Combining IGF-1 with Testosterone

Scientific evidence supports that elevated IGF-1 levels combined with elevated testosterone levels yield even greater muscle hypertrophy. IGF-1’s role as a critical mediator of muscle growth by stimulating both muscle cell hyperplasia (an increase in number of muscle cells) and muscle hypertrophy (muscle cell growth) makes it the most effective muscle-building hormone. When combined with testosterone, another powerful hormone, which induces anabolic muscle hypertrophy, muscle building is further enhanced. The dual hypertrophic (muscle building) effects of IGF-1 and testosterone allow for the newly formed IGF-1 stimulated muscle cells to develop, mature and grow. The synergistic effects of having more muscles cells and having these muscle cells grow at a faster rate results in a significant gain in lean body mass.

An optimal program for muscle growth would be to combine HexaGHen with MuscleMEDs’ pharmadynamic testosterone optimizer ARIMATEST. ARIMATEST is an anti-aromatase inhibitor with very powerful testosterone elevating effects, made possible through the utilization of advanced anti-aromatase bioactives provided in the advanced sub-buccal FASTSORB delivery tablet. Arimatest has the unique ability to rapidly and dramatically increase free testosterone while eliminating estrogen through aromatase inhibition. ARIMATEST is for use by adult males only.

HEXAGHEN
How Supplied
FASTSORB TABLETS
12.6 mg/per serving
56 tablets per box
Contains two, 28 tablet dispensers

•Store at 15-30º C (59-86ºF).
•Protect from heat, light and moisture.
•Keep out of reach of children.
Testing methodologies vary. Advertised results may not be typical.



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